Efficacy

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1Kazda C, Húlstrunk H, Helsberg K, et al. Prandial insulin substitution with insulin lispro or insulin lispro mid mixture vs. basal therapy with insulin glargine: a randomized controlled trial in patients with type 2 diabetes beginning insulin therapy. J Diabetes Complications. 2006;20:145-152.
2Polonsky KS, Given BD, Hirsch LJ, et al. Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 1988; 318:1231-1239.
3Heinemann L, Linkeschova R, Rave K, et al. Time-action profile of the long-acting insulin analog insulin glargine (H0E901) in comparison with those of NPH insulin and placebo. Diabetes Care 2000;23:644-649.
4Howey DC, Bowsher RR, Brunelle RL and Woodworth JR. [Lys(B28), Pro(B29)] - human insulin: a rapidly absorbed analogue of human insulin. Diabetes 1994;43:396-402.
5Anderson JH Jr, Brunelle RL, Keohane P, et al. Mealtime treatment with insulin analog improves postprandial hyperglycemia and hypoglycemia in patients with non-insulin- dependent diabetes mellitus. Arch Intern Med 1997;157:1249-1255.

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1Malone et al, Twice-daily pre-mixed insulin rather than basal insulin therapy alone results in better overall glycaemic control in patients with Type 2 diabetes. Diabetic Medicine. 2005: 22, 374–381



Last Update: 2 Nov 15

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