How CIALIS Works

When sexual stimulation occurs, nerve endings in the penis and endothelial cells in the corpora cavernosa release nitric oxide (NO). Nitric oxide stimulates the production of cGMP, causing the smooth muscle cells to relax, allowing increased blood flow to the corpora cavernosa. The increased blood flow causes the penis to expand and become firm. As the penis becomes engorged with blood, the expanding erectile tissue compresses the penile veins. Decreased blood outflow allows the penis to become engorged. Following ejaculation, cessation of sexual stimuli, or negative stimuli, PDE5 degrades cGMP, ultimately ending the erection.

Cialis decreases the breakdown of cGMP by inhibiting the action of PDE5. This results in maintained or an increased level of cGMP in the penile vasculature. Blood flow into the corpora cavernosa is increased, causing it to expand. Sufficient expansion of the corpora cavernosa compresses the veins and decreases blood outflow. By decreasing the breakdown of cGMP, Cialis helps the body attain and maintain an erection for a sufficient amount of time to allow successful sexual intercourse to occur. Sexual stimulation is necessary for Cialis to be effective.

How Cialis Works

HKGCIA2015-09-29T13_29_38


1Hong Kong Cialis product insert, version PA007SPHK01


Last Update: 6 Oct 2015

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