How ZYPREXA works

ZYPREXA is a kind of medication known as an atypical antipsychotic. Antipsychotic medicines are used to treat the symptoms of psychotic disorders, such as schizophrenia. They may also be prescribed to treat acute mixed or manic episodes of bipolar I disorder.


Absorption. After an oral dose, ZYPREXA® is well absorbed by the gastrointestinal system, unaffected by food. ZYPREXA® reaches its peak plasma concentration within approximately 5 - 8 hours.

Distribution. ZYPREXA® is distributed throughout the body and is highly bound to plasma proteins (93%).

Metabolism. ZYPREXA® is highly metabolized, with only 7% of the dose excreted unchanged in urine. Its metabolism may vary based on smoking status, gender ans age.

Elimination. ZYPREXA® and its metabolites are excreted in urine and feces. ZYPREXA® has linear pharmacokinetics, with a mean half-life of 30 hours (range: 21 to 54 hours).

Clearance and volume of distribution. The volume of distribution for ZYPREXA® is approximately 1,000 L. The mean rate of plasma clearance for ZYPREXA® is 25L/hr.


Last Update: 6 Oct 15